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Page 1
Human skin-derived ABCB5(+) stem cell injection improves liver disease parameters in Mdr2KO mice.
Hartwig V, Dewidar B, Lin T, Dropmann A, Ganss C, Kluth MA, Tappenbeck N, Tietze L, Christ B, Frank M, Vogelmann R, Ebert MPA, Dooley S. Hartwig V, et al. Arch Toxicol. 2019 Sep;93(9):2645-2660. doi: 10.1007/s00204-019-02533-3. Epub 2019 Aug 21. Arch Toxicol. 2019. PMID: 31435712
Although liver transplantation is a potential effective cure for patients with end-stage liver diseases, this strategy has several drawbacks including high cost, long waiting list, and limited availability of liver organs. ...Taken together, ABCB5 …
Although liver transplantation is a potential effective cure for patients with end-stage liver diseases, this strategy …
Genetic variation in ABCB5 associates with risk of hepatocellular carcinoma.
Leung IC, Chong CC, Cheung TT, Yeung PC, Ng KK, Lai PB, Chan SL, Chan AW, Tang PM, Cheung ST. Leung IC, et al. J Cell Mol Med. 2020 Sep;24(18):10705-10713. doi: 10.1111/jcmm.15691. Epub 2020 Aug 11. J Cell Mol Med. 2020. PMID: 32783366 Free PMC article.
A total of 300 HCC and 300 healthy blood DNA samples were then examined by Sequenom MassARRAY genotyping and pyrosequencing for 38 SNP and 1 INDEL in ABCB5. Five novel SNPs were identified in ABCB5. Comparison of DNA from blood samples of HCC and healthy demonstrate …
A total of 300 HCC and 300 healthy blood DNA samples were then examined by Sequenom MassARRAY genotyping and pyrosequencing for 38 SNP and 1 …
Granulin-epithelin precursor and ATP-dependent binding cassette (ABC)B5 regulate liver cancer cell chemoresistance.
Cheung ST, Cheung PF, Cheng CK, Wong NC, Fan ST. Cheung ST, et al. Gastroenterology. 2011 Jan;140(1):344-55. doi: 10.1053/j.gastro.2010.07.049. Epub 2010 Aug 2. Gastroenterology. 2011. PMID: 20682318
Expression levels of GEP and ABCB5 were correlated in human liver tumor samples. ABCB5 levels were increased in liver cancer cells compared with nontumor liver tissue from patients with cirrhosis or hepatitis, or normal liver tissue. ...C …
Expression levels of GEP and ABCB5 were correlated in human liver tumor samples. ABCB5 levels were increased in live …
Novel biomarkers GEP/ABCB5 regulate response to adjuvant transarterial chemoembolization after curative hepatectomy for hepatocellular carcinoma.
Chong CC, Cheung ST, Cheung YS, Chan AW, Chan SL, Yu SC, Lai PB. Chong CC, et al. Hepatobiliary Pancreat Dis Int. 2018 Dec;17(6):524-530. doi: 10.1016/j.hbpd.2018.10.003. Epub 2018 Oct 29. Hepatobiliary Pancreat Dis Int. 2018. PMID: 30413348
We had previously demonstrated that expression of Granulin-epithelin precursor (GEP) and ATP-dependent binding cassette (ABC)B5 in liver cancer stem cells was associated with chemoresistance. The present study aimed to evaluate the association between GEP/ABCB5 expr …
We had previously demonstrated that expression of Granulin-epithelin precursor (GEP) and ATP-dependent binding cassette (ABC)B5 in liver …
Assessment of the hepatocytic differentiation ability of human skin-derived ABCB5(+) stem cells.
Tietze L, Winkler S, Hempel M, Kluth MA, Tappenbeck N, Ganss C, Dooley S, Christ B. Tietze L, et al. Exp Cell Res. 2018 Aug 15;369(2):335-347. doi: 10.1016/j.yexcr.2018.05.040. Epub 2018 Jun 1. Exp Cell Res. 2018. PMID: 29864400
The continuously decreasing willingness for liver donation aggravates treatment of end-stage liver diseases requiring organ transplantation as the only curative strategy. ...Since most of chronic liver diseases involve exaggerating immune mechan …
The continuously decreasing willingness for liver donation aggravates treatment of end-stage liver diseases requiring o …
Antibody against granulin-epithelin precursor sensitizes hepatocellular carcinoma to chemotherapeutic agents.
Wong NC, Cheung PF, Yip CW, Chan KF, Ng IO, Fan ST, Cheung ST. Wong NC, et al. Mol Cancer Ther. 2014 Dec;13(12):3001-12. doi: 10.1158/1535-7163.MCT-14-0012. Epub 2014 Sep 24. Mol Cancer Ther. 2014. PMID: 25253787
Combination therapy was compared with monotherapy using hepatocellular carcinoma (HCC) cells in vitro and orthotopic liver tumor models in vivo. CD133 and related hepatic CSC marker expressions were investigated by flow cytometry. ...We demonstrated that HCC cells that sur …
Combination therapy was compared with monotherapy using hepatocellular carcinoma (HCC) cells in vitro and orthotopic liver tumor mode …
Granulin-epithelin precursor is an oncofetal protein defining hepatic cancer stem cells.
Cheung PF, Cheng CK, Wong NC, Ho JC, Yip CW, Lui VC, Cheung AN, Fan ST, Cheung ST. Cheung PF, et al. PLoS One. 2011;6(12):e28246. doi: 10.1371/journal.pone.0028246. Epub 2011 Dec 16. PLoS One. 2011. PMID: 22194816 Free PMC article.
METHODS: Protein expression of GEP in fetal and adult livers was examined in human and mouse models by immunohistochemical staining and flow cytometry. Liver cancer cell lines, isolated based on their GEP and/or ATP-dependent binding cassette (ABC) drug transporter ABCB …
METHODS: Protein expression of GEP in fetal and adult livers was examined in human and mouse models by immunohistochemical staining and flow …
Hepatic cancer stem cell marker granulin-epithelin precursor and β-catenin expression associate with recurrence in hepatocellular carcinoma.
Cheung PF, Cheung TT, Yip CW, Ng LW, Fung SW, Lo CM, Fan ST, Cheung ST. Cheung PF, et al. Oncotarget. 2016 Apr 19;7(16):21644-57. doi: 10.18632/oncotarget.7803. Oncotarget. 2016. PMID: 26942873 Free PMC article.
GEP protein levels were significantly higher in HCCs than the paralleled non-tumor liver tissues, and associated with venous infiltration. GEPhigh cells isolated from clinical HCC samples exhibited higher levels of stem cell marker CD133, pluripotency-associated signaling …
GEP protein levels were significantly higher in HCCs than the paralleled non-tumor liver tissues, and associated with venous infiltra …
Association of ATP-Binding Cassette Transporter (ABC) Gene Polymorphisms with Viral Load in Patients with Genotype 1 Hepatitis C Virus Infection.
Chen L, Rao H, Zhang W, Liu F, Jiang D, Wei L. Chen L, et al. Clin Lab. 2016 Sep 1;62(9):1643-1649. doi: 10.7754/Clin.Lab.2016.160105. Clin Lab. 2016. PMID: 28164591
METHODS: We recruited 347 Chinese Han patients chronically infected with genotype 1 HCV in this study. Ten single nucleotide polymorphism (SNPs) in ABCA1, ABCB5, ABCB11, ABCG2, ABCG5, ABCG10 were analyzed by custom chip from Illumina. ...
METHODS: We recruited 347 Chinese Han patients chronically infected with genotype 1 HCV in this study. Ten single nucleotide polymorphism (S …